Phosphoenolpyruvate in rat pancreatic islets: A possible intracellular trigger of insulin release?
نویسندگان
چکیده
منابع مشابه
Effect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets
Objective: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level.This study was undertaken to investigateits direct effect on the islets of Langerhans. Material and Methods: Male albino Wistar rats were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. The islets were incubated for 60 min in Krebs bicarbonate buffer containi...
متن کاملeffect of ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets
objective: ganoderma lucidum (g. lucidum) has been suggested to increase serum insulin level.this study was undertaken to investigateits direct effect on the islets of langerhans. material and methods: male albino wistar rats were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. the islets were incubated for 60 min in krebs bicarbonate buffer containin...
متن کاملBiphasic insulin release in rat islets of Langerhans and the role of Intracellular Ca++ stores.
The role of extracellular Ca++ in the development of biphasic insulin release has been studied previously by using Verapamil to block the glucose-induced stimulation of Ca++ uptake. It was found that glucose-stimulated uptake of ca++ from the extracellular fluid was important for the second phase of insulin release but had no role in the first phase. In the current study, the role of intracellu...
متن کاملEffects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets.
Galanin is a neurotransmitter peptide that suppresses insulin secretion. The present study aimed at investigating how a non-peptide galanin receptor agonist, galnon, affects insulin secretion from isolated pancreatic islets of healthy Wistar and diabetic Goto-Kakizaki (GK) rats. Galnon stimulated insulin release potently in isolated Wistar rat islets; 100 microM of the compound increased the re...
متن کاملThe roles of intracellular and extracellular Ca++ in glucose-stimulated biphasic insulin release by rat islets.
Verapamil, an agent known rapidly to block calcium uptake into islets of Langerhans, has been used to study the roles of intra- and extracellular calcium in the two phases of glucose-induced insulin release. Rates of calcium uptake and insulin release during the first phase were measured simultaneously over 5 min in rat islets after maintenance in tissue culture for 2 days. Rates of (45)Ca(++) ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1977
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf01234500